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UID:6b6753b2a23204df360f9a212320e018
DTSTAMP:20261017T151358Z
SUMMARY:Zexin Li - Institutionen för experimentell medicinsk vetenskap
DESCRIPTION:Kontakt: zexin.li@med.lu.se\n\nTitle: Characterisation and disc
 overy of conflict-associated systems in plant-associated prophagesMain sup
 ervisor: Gemma C. AtkinsonReviewers: Catherine Paul\, Dag Ahren\, Jeovanis
  Gil ValdésAbstract(Bacterio)phages\, viruses that infect bacteria\, play
  an important role in cellular and molecular evolution and microbial ecolo
 gy. In the lysogenic life cycle\, phages integrate their DNA into bacteria
 l genomes as prophages. Prophages often carry cargo genes that influence h
 ost fitness. Many of these cargo genes are involved in inter-species biolo
 gical conflict\, such as anti-phage defence systems and toxins. Phage defe
 nce systems protect bacteria against phage infection\, but when encoded on
  prophages can be seen as phage weapons to inhibit competing phages. These
  anti-phage defence systems often contain toxins that inhibit bacterial gr
 owth to limit spread of the viral infection. In the case of symbionts and 
 pathogens\, toxins can be bacterial effector proteins that mediate interac
 tions with eukaryotic hosts. Here\, we investigated the anti-phage defence
  systems in the plant pathogenic bacteria Ralstonia solanacearum species c
 omplex\, and aim to discover previously unknown anti-phage defence systems
 . To address this\, we mined Ralstonia prophage hotspots and identified pu
 tative anti-phage defence systems\, in which a representative candidate wa
 s further validated for defensive activity by phage assay. We next analyse
 d anti-eukaryote toxin cassettes carried by APSE phages\, which reside in 
 insect symbiont bacteria Candidatus Hamiltonella defensa and contribute to
  aphid protection against parasitoid wasps\, revealing extensive structura
 l and functional diversity among APSE-encoded toxins. Together\, our findi
 ngs highlighted that the prophage hotspots are important reservoirs of ada
 ptive genes\, particularly those involved in biological conflict.\n\nMer i
 nformation om händelsen: https://www.intramed.lu.se/evenemang/zexin-li-in
 stitutionen-experimentell-medicinsk-vetenskap
DTSTART;TZID=GMT:20260818T120000
DTEND;TZID=GMT:20260818T120000
LOCATION:BMC Sölvegatan 19 room C1303b 
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